Crohn's disease. — crohn • RBesT

Data set containing historical information for placebo arm of relevant studies for the treatment of Crohn's disease. The primary outcome is change from baseline in Crohn's Disease Activity Index (CDAI) over a duration of 6 weeks. Standard deviation of change from baseline endpoint is approximately 88.

Usage

crohn

Format

A data frame with 4 rows and 3 variables:

study: study
n: study size
y: mean CDAI change

References

Hueber W, Sands BE, Lewitzky S, Vandemeulebroecke M, others (2012). “Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease.” Gut, 61(12), 1693–1700.

Examples

.user_mc_options <- options()

set.seed(546346)
map_crohn <- gMAP(cbind(y, y.se) ~ 1 | study,
  family = gaussian,
  data = transform(crohn, y.se = 88 / sqrt(n)),
  weights = n,
  tau.dist = "HalfNormal", tau.prior = 44,
  beta.prior = cbind(0, 88)
)
## Recover user set sampling defaults
options(.user_mc_options)