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Dataset: historical data on two single-agents to inform a combination study

Source: R/hist_combo2.R
hist_combo2.Rd

One of two datasets from the application described in Neuenschwander et al (2016). The risk of DLT is to be studied as a function of dose for two drugs, drug A and drug B. Historical information on the toxicity profiles of these two drugs is available from single agent trials trial_A and trial_B. A second dataset codata_combo2 is available from this application, which includes additional dose-toxicity data from trial_AB and IIT of the combination of Drugs A and B.

Usage

hist_combo2

Format

A tibble with 11 rows and 5 variables:

group_id

study

drug_A

dose of Drug A

drug_B

dose of Drug B

num_patients

number of patients

num_toxicities

number of DLTs

cohort_time

cohort number of patients

References

Neuenschwander B, Roychoudhury S, Schmidli H (2016). “On the use of co-data in clinical trials.” Statistics in Biopharmaceutical Research, 8(3), 345–354. doi:10.1080/19466315.2016.1174149 .