Produce an xgx-styled report the given dataset using xgx R markdown templates, or a user-provided R markdown template. (Note: The R markdown template provided must be formatted in a similar manner to that of the xgx R markdown templates to work.) The working directory will contain a new directory (`xgx_autoexplore_output`) after running this function, which will contain a directory for the dataset, and futher a directory for the type of analysis / R markdown template.

xgx_auto_explore returns an HTML and PDF document with plots describing the provided dataset

xgx_auto_explore(
  data_path = NULL,
  mapping = list(),
  author_name = NULL,
  multiple_dosing = FALSE,
  pk_cmt = NULL,
  pd_cmt = NULL,
  pd_data_type = NULL,
  dose_cmt = NULL,
  steady_state_day = NULL,
  time_between_doses = NULL,
  rmd_template_name = NULL,
  rmd_template_path = NULL,
  rmd_output_path = NULL,
  pdf_output_path = NULL,
  html_output_path = NULL,
  add_datetime = TRUE,
  show_explanation = TRUE
)

Arguments

data_path

Path (as a string) to the dataset that is to be analyzed

mapping

A list of column name mappings from the original (template) dataset column names to the corresponding columns in the new dataset.

author_name

The name of the author to be displayed on the template

multiple_dosing

Whether or not to use a "Multiple" or "Single" Ascending dose template

pk_cmt

An integer denoting the "compartment" containing the PK data. The "CMT" column will typically have these integers, where each row may contain PK, PD, dosing or other events/observations data

pd_cmt

An integer denoting the "compartment" containing the PD data, of the desired type (continuous, ordinal, etc.). The "CMT" column will typically have these integers, where each row may contain PK, PD, dosing or other events/observations data

pd_data_type

The type of PD data - acceptable values exist in the following list: ["binary","continuous","count","ordinal","real_example","receptor_occupancy","time_to_event"]

dose_cmt

Integer denoting the compartment for dosing records

steady_state_day

used to denote the day of rich sampling of PK at steady state

time_between_doses

dosing interval, has units to match the time variable of the dataset

rmd_template_name

A custom output name for the generated Rmd file

rmd_template_path

A user provided custom template (as a string)

rmd_output_path

A custom output path for the generated Rmd file (This is typically left as `NULL` in order to maintain the hierarchical directory structure of `xgx_autoexplore_output`))

pdf_output_path

A custom output path for the generated PDF file (This is typically left as `NULL` in order to maintain the hierarchical directory structure of `xgx_autoexplore_output`))

html_output_path

A custom output path for the generated HTML file (This is typically left as `NULL` in order to maintain the hierarchical directory structure of `xgx_autoexplore_output`))

add_datetime

Boolean indicating additon of a date stamp to the beginnning of the Rmd file

show_explanation

Boolean indicating if the additional explanations (text in between figures) are needed for the user.

Details

This function can be used quickly to explore your data by generating overview plots before constructing non-linear mixed effects models.

Examples

author_name = "Your Name Here"
show_explanation = FALSE

if (FALSE) {
# Try out the nonlinear_pkpd dataset with the
# Multiple Ascending Dose PK Rmd template
data_path <- "~/nonlinear_pkpd.csv"

# Specify the mapping of column names
mapping <- list(
  "TIME" = "TIM2",
  "NOMTIME" = "NT",
  "EVID" = 0,
  "CENS" = 0,
  "DOSE" = "MGKG",
  "TRTACT" = "TRT",
  "LIDV_NORM" = "LIDV/MGKG",
  "LIDV_UNIT" = "UNIT",
  "PROFDAY" = 1,
  "SEX" = 0,
  "WEIGHTB" = 0)


# 5 contains the PK Concentration in this dataset
pk_cmt = 5
# We don't need PD right now
pd_cmt = NULL
pd_data_type = NULL


dose_cmt = 1
steady_state_day = c(0, 6)
time_between_doses = 24
multiple_dosing = TRUE

output_directory = tempdir()

xgx_auto_explore(data_path = data_path,
                 mapping = mapping,
                 author_name = author_name,
                 pk_cmt = pk_cmt,
                 pd_cmt = pd_cmt,
                 dose_cmt = dose_cmt,
                 steady_state_day = steady_state_day,
                 time_between_doses = time_between_doses,
                 multiple_dosing = multiple_dosing,
                 pd_data_type = pd_data_type,
                 rmd_output_path = output_directory,
                 show_explanation = show_explanation)
}